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ID 41207
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Title Alternative
Clinical and Experimental Studies on the Ototoxity of Dihydrostreptomycin Part 1. Clinical Observations on the Ototoxity of Dihydrostreptomycin
Author
Takamatsu, Makoto
Abstract
As the results of various examinations conducted on 367 patients, suffering from lung tuberculosis and having received dihydrostreptomycin (DHSM.), twenty-seven cases of them, seven percent, revealed the hearing impairment apparently caused by DHSM The author studied carefully the inter-relationship among such factor as the initial symptoms and the time of the onset of these symptoms, the type and the degree of hearingloss, the total dosage of the drug given to each patient up to the onset of cochlear symptoms, the duration of time elapsed up to the fixation of hearingloss, and the treatment; and obtained the following findings. 1) Tinnitus is an important symptoms in the early stage previous to the appearance of disturbances in hearing. 2) The disturbances in hearing caused by this drug at the early stages are marked in the high tonel level up to 8000 cps. Moreover, it is noticeable that there exists a typical type of hearing impairment, namely the type that decends abruptly just at 8000 cps. 3) The appearance of such disturbances is greatly correlated with individual susceptibility, namely, with his congenital factor. 4) The early discovery of these disturbances can only be attained by frequent and scrutinous examinations of hearing. 5) As for the prognosis of these disturbances, the cessation of the administration of this drug after a relatively early discovery can sometimes improve the conditions though slightly. 6) Though there are hardly any cases whose tinitus as well as the hearingloss have improved after the treatments by VB(1), VA, a decrease or disappearance only of tinitus with a subsequent improvement in subjective hearing has been recognized in some cases.
Published Date
1959-09-20
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume71
Issue
issue10-1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
6669
End Page
6677
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/71/10-1/71_10-1_6669/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma