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ID 40738
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Title Alternative
The influence of HCO(3) -induced and CO(2) -induced pH changes on the action of non-depolarizing muscle relaxants in rats
Author
Nagano, Osamu
Abstract
The influences of HCO(3)-induced and CO(2)-induced pH changes on the action of nondepolarizing muscle relaxants (MRs) were investigated using a rat phrenic nervehemidiaphragm preparation. Changes in pH were induced by varying HCO(3) concentration of the modified Krebs' solution (mK') or by varying the CO(2) concentration in the gas aerating the mK'. Changes in [Ca(++)] and [Mg(++)], associated with changes in HCO(3) concentration, were measured and corrected. A change in HCO(3) from 50mM to 13.5mM or a change in CO(2) from 2.5% to 9%, augmented the partial neromuscular blockade produced by d-Tc or vecuronium (p<0.01), while inhibiting that produced by metocurine or pancuronium (p<0.01). A change in HCO(3) from 13.5mM to 50mM or a change in CO(2) from 9% to 2.5%, inhibited the partial neuromuscular blockade produced by d-Tc or vecuronium (p<0.01), while augmenting that produced by metocurine or pancuronium (p<0.01). These findings suggest that the HCO(3)-induced and CO(2)-induced pH changes have a similar influence on the action of MRs. A difference exists between mono- and bisquaternary MRs with regard to their response to pH changes.
Keywords
非脱分極性筋弛緩薬
代謝性pH変化
呼吸性pH変化
筋弛緩作用
Published Date
1989-04
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume101
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
387
End Page
394
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/101/3-4/101_3-4_387/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
OAI-PMH Set
岡山大学
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Sort Key
9
Eprints Journal Name
joma