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ID 40728
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Title Alternative
Methemoglobin formation from hemoglobin by nitrite ion in the erythrocytes of normal and acatalasemic mice; in vivo and in vitro study
Author
Ioku, Naoya
Abstract
The formation of methemoglobin from hemoglobin by nitrite ion in the erythrocytes of normal and acatalasemic mice and that in the erythrocytes of both mice injected with nitrite ion were studied. The formation of methemoglobin from hemoglobin by nitrite ion in red cells with or without the addition of glucose in vitro was also studied. Methemoglobin concentration in red cells of acatalasemic mice after the addition of NaNO(2) was higher than that in red cells of normal mice. The addition of glucose inhibited the formation of methemoglobin from hemoglobin by nitrite ion. Methemoglobin concentration in the blood of mice injected with NaNO(2) (1550μg/g) was determined. The results indicated that methemoglobin concentration in the blood of acatalasemic mice is higher than that in the blood of normal mice. These results indicated that the formation of methemoglobin from hemoglobin by nitrite ion appears to be controlled by the activity of blood catalase.
Keywords
亜硝酸イオン
カタラーゼ
メトヘモグロビン
Published Date
1989-02
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume101
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
223
End Page
231
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/101/1-2/101_1-2_223/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma