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ID 34207
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Author
Ali, Hamed I..
Tomita, Keiichiro
Akaho, Eiichi
Kambara, Hiroto
Miura, Shinji
Hayakawa, Hiroyuki
Ashida, Noriyuki
Kawashima, Yutaka
Yamagishi, Takehiro
Ikeya, Hisao
Yoneda, Fumio
Abstract
Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, and KB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A 431 human adenocarcinoma cells transplanted subcutaneously into nude mouse. Furthermore, AutoDock study has been done by binding of the flavin analogs into PTK pp60(c-src), where a good correlation between their IC50 and AutoDock binding free energy was exhibited. In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK.
Keywords
antitumor activity
Flavin analog
AutoDock
protein tyrosine kinase
Note
Published with permission from the copyright holder.
This is a author's copy,as published in Bioorganic & Medicinal Chemistry , 2007 Vol.15 Issue.1 pp.242-256
Publisher URL: http://dx.doi.org/10.1016/j.bmc.2006.09.063
Direct access to Thomson Web of Science record
Copyright © 2007 by Elsevier Ltd.
Published Date
2007-01-01
Publication Title
Bioorganic & Medicinal Chemistry
Volume
volume15
Issue
issue1
Publisher
Pergamon-Elsevier Science Ltd.
Start Page
242
End Page
256
ISSN
0968-0896
NCID
AA10938083
Content Type
Journal Article
language
英語
Copyright Holders
Elsevier Ltd.
File Version
author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT
Submission Path
organic_chemistry/11