ID 30954
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Author
Nakanishi, Akira
Abe, Tadashi
Abstract

Testicular Sertoli cells highly express dynamin 2 and amphiphysin 1. Here we demonstrate that dynamin 2 is implicated in phosphatidylserine (PS)-dependent phagocytosis in Sertoli cells. Immunofluorescence and dual-live imaging revealed that dynamin 2 and amphiphysin 1 accumulate simultaneously at ruffles. These proteins are specifically bound in vitro. Over-expression of dominant negative dynamin 2 (K44A) inhibits liposome-uptake and leads to the mis-localization of amphiphysin 1. Thus, the cooperative function of dynamin 2 and amphiphysin 1 in PS-dependent phagocytosis is strongly suggested.

Keywords
dynamin
amphiphysin
phagocytosis
testis
Amo Type
Original Article
Published Date
2008-12
Publication Title
Acta Medica Okayama
Volume
volume62
Issue
issue6
Publisher
Okayama University Medical School
Start Page
385
End Page
391
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
Web of Sience KeyUT