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ID 19784
Eprint ID
19784
FullText URL
Thumnail 68_1415.pdf 896 KB
Title Alternative
Fundamental and Clinical Studies on Medical Treatment of Moniliasis with Photosensitizing Dyes. Part. Ⅰ The relation between constitutional formulas of photosensitizing dyes and anticandida action and influences of photosensitizing dye NK 91 upon Candida albicans
Author
Yamaguchi, Yoshio
Abstract
The author has investigated a specific fungiostatic action against Candida albicans Tanimoto by using 109 different species of photosensitizing dyes, classifing them into groups according to their constitutional formulas. Among so many species photosensitizing dye NK 91 which belongs to Styril type showed the strongest fungiostatic action and scareely decreased its effect by adding serum. The results obtained can be summarized as follows: 1) In respect of the types of dyes, Monomethin, Trimethin, Heptamethin, Cyanin and Styril types showed a strong fungiostatic action. 2) In respect of the radical nucleus (of dyes, Benzothiazol. Naphtothiazol and Chinorin nucleus showed a moderate fungiostatic action). 3) In respect of the alkyl radical, high alkyl did not always show the fungiostatic effect. 4) In regard to Halogen and acid radical, eight kinds of iodine radical, one kind of bromine radical, and three kinds of acid radical were efficacious. 5) NK 91 changed remarkably the shape of Candida albicans and moreover in the high concentration, perished utterly Candida albicans. 6) NK 91 inhibited the decline of pH of Sabouraud-glucose medium in which Candida albicans was inoculated. 7) The respiration of Candida albicans was inhibited and its oxygen consumption lowered by NK 91.
Published Date
1956-09-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume68
Issue
issue9
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1415
End Page
1427
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/68/9/68_9_1415/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma