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ID 18816
Eprint ID
18816
FullText URL
Thumnail 73_399.pdf 11.3 MB
Title Alternative
Studies on Anti-leukemic Chemical Agents -By the Bone-Marrow Tissue Culture- Ⅰ. The Effects of Anti-leukemic Chemical Agents on the Bone-Marrow Tissse Culture of Normal Rabbit and Normal Person
Author
Sato, Shiro
Abstract
In order to clarify the effects of anti-leukemic clemical agents-antimetabolites (Azan, 6MP, T-431L), hormones (ACTH, Cortisone, Prednisolone)-on the hematopoietic function of bone marrow, especially on the leucocyte series, the author observed the effects of direct addition of these chemical agents on the tissue growth area, the cell density, and the wandering velocity of pseudoeosinophils of the bone marrow by performing the tissue culture of the normal rabbit bone marrow. Likewise, the bone-narrow tissue culture of normal persons has been performed with the addition of several anti-leukemic chemical agents at various concentrations, and established the maximal concentration of the agents in the medium as to not impede the bone-marrow growth; and obtained the following results. 1. Any one of anti-leukemic agents acts inhibitorily on the cell growth and the wandering velocity of the cells of the bone marrow at a higher concentration than at a certain fixed concentration. Of the anitmetabolites used in the present experiments, the inhibitory effect is strong in the descending order of T-431L, Azan and 6MP; and of the hormones it is in the order of Prednisolone, Cortisone and ACTH. 2. The maximal concentration of the media with addition of several anti-leukemic agents, which do not impede the growth of the bone marrow of normal persons is 0.035 mg/ml for Azan; 0.05 mg./ml. for 6MP; 0.01 mg/ml. for T-431L; 0.01 mg/ml. for ACTH; 0.01 mg/ml. for Cortisone ; and 0.01 mg/ml. for Prednisolone.
Published Date
1961-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume73
Issue
issue4-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
399
End Page
407
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/73/4-6/73_4-6_399/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma