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ID 18625
Eprint ID
18625
FullText URL
Thumnail 72_1343.pdf 5.56 MB
Title Alternative
Studies on Alkylphosphate Poisoning Part 2. Toxicity and In Vivo Distribution of PAM (pyridine-2-aldoxime methiodide)
Author
Okazaki, Shoichi
Abstract
In the use of any drug there always arise problems of its effect and side-effect as well as its toxicity and distribution in vivo. Therefore, the author studied these problems on PAM from various angles and obtained the following results. 1. The median lethal dosage (LD(50)) of PAM on mice has been found to be: 159 mg/kg in the case of intravenous administration; 247 mg/kg in peritoneal injection; 340 mg/kg in subcutaneous injection; and 1960 mg/kg in oral administration, proving that the limit is sufficiently within the range of commonly used drugs. 2. Histological changes occurring after PAM adminstration are consisted mainly of disturbances in the circulatory system, namely, hyperemia, congestion and slight hemorrhage, but rarely of parenchymal disturbances. 3. When a large amount of PAM is administered to rabbits, there occurs a rise in the blood cholinesterase activity at first later followed by its fall. However, the fall being down to -25 per cent, it can not be considered as due to the toxicity of PAM. 4. In the oral adminstration of PAM to rabbits, PAM can be detected considerably in stomach, intestines, and in their contents, but it is distributed fairly evenly in other viscera. Moreover, in the case of the intravenous administration of PAM is also distributed in similar manner. It diminishes relatively promptly from the body fluid. Judging from these findings as well as from results of clinical observations, there is no danger of toxicity of PAM in the amount as used in our clinic.
Published Date
1960-07-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume72
Issue
issue5-7
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1343
End Page
1349
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/72/5-7/72_5-7_1343/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma