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ID 18549
Eprint ID
18549
FullText URL
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Title Alternative
Studies On Diencephalo-Pituitary-Adrenocortical Function in Depressive Psychosis 1. On Urinary Steroid Patterns
Author
Tsuji, Harunori
Abstract
Although there are many reports concerning the endocrinological studies in mental diseases, no general agreement has yet been reached. Investigating the depressive psychosis, the author gave a special consideration to the problem whether there are any specific relations between the urinary corticoid patterns and clinical state. Twenty-four hour urines were collected from 20 males and 20 females, both healthy persons (ranging 22-47 years old in age, the average being adout 25 years) as controls, and 28 cases of depressive psychosis, consisted of 14 males and 14 females (ranging 22-68 years old, 42 years in average) composed of 4 reactive, 2 agitated and 5 brain arteriosclerotic depressive state. Measurements were taken on total neutral 17-ketosteroid (17-KS), total 17-hydroxycorticoid (17-OHCS) and free and conjugated forms of the latter. 17-KS was measured by the modified Holtorff and Koch's method and Bongiovanni's method. The results are as follows: (Every value shows mean and standard deviation). 1. Dialy excretion of total 17-KS in the controls was 7.63±2.71 mg/day for males and 5.67-1,67 mg/day for females. The difference between both sexes is thought to be significant from the statistical standpoint. Daily control excretion of 17-OHCS of males was 6.13±1.74 mg/day as the total amount, 0.88±0.51 mg/day as free form, 5.26±1.57 mg/day as conjugated form, 8.12±4.95 as the ratio of conjugated form/free form (C/F), and 86.18±6.28 as the percentage of conjugated form/total (C/T%); that of females was 5.48±2.07 mg/day as total, 0.65±0.42 mg/day as free form, 4.83±1.84 mg/day as conjugated form, 9.50±4.85 as C/F and 88.06±5.87 as C/T%. The difference between sexes appears to be insignificant. 2. Depressive group: Total 17-KS was 5.42±2.83 mg/day for males and 4.97±2.05 mg/day for females, being lower than normal value, and the former was significant but the latter insignificant from the statistical standpoint. Total 17-OHCS was 5.42±2.86 mg/day for males and 3.83±1.68 mg/day for females, being lower than normal value, which means that the former is insignificant while the latter significant. Free 17-OHCS was 2.17±1.18 mg/day for males and 1.19±0.82 mg/day for females, 2 times or more than normal value, and those of both sexes were significant. Conjugated 17 OHCS was 3.25±1.90 mg/day for males and 2.64±1.92 mg/day for females, lower than normal value, being significant for both sexes. 3. In comparing all the depressive groups with small groups of 2 agitated, 4 reactive and 5 cerebral arteriosclerotic depressives, there were no significant differences but the two agitated in the small groups showed the lowest values of all the depressives, namely, total 17-KS, total 17-OHCS, conjugated from and C/F ratio all proved to be much lower than those in the other depressives. 4. Total 17-OHCS values of 5 cases after treatment were found to have been increased, free 17-OHCS decreased, and conjugated form increased. As the result of the increase in the C/F and C/T % , the corticoid patterns approached the normal. 5. The author investigated the relation of corticoid patterns and liver dysfunction, then depressive psychosis and schizophrenia. Incomparing schrzophrenia with depressive psychosis, 17-KS value of the latter was found to approximate that of acute schizophrenics and total 17-OHCS value of the latter to that of chronic schizophrenics in both sexes. From these findings it seems that depressive psychosis indicates the diencephalo-pituitary-adrenccortical dysfunction more significantly than schizophrenia.
Published Date
1963-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume75
Issue
issue4-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
431
End Page
445
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/75/4-6/75_4-6_431/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma