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ID 18518
Eprint ID
18518
FullText URL
Thumnail 72_545.pdf 613 KB
Title Alternative
Histological Studies on Experimental Hepatitis Part 1. On the Histological Changes of the Internal Organs of Mouse Following the Oral Administrations of the Various Concentrations of Arsenious Acid
Author
Endo, Kenichi
Abstract
Observing the histological changes of the internal organs of mouse following the oral administrations of 0.5 cc of arsenious acid in various concentrations, and the following results were obtained. 1. In the cases given 0.5 and 1.0% of arsenious acid orally, marked degenerations of the parenchymal cells ware observed mainly in the kidney and heart. But, vascular damages were present in every organ, especially evident in the liver and spleen; hypertrophy of stelliform cells, destruction, dilatation, hyperemia, swelling and roughness of the vascular walls. 2. In the cases given daily 0.05% arsenious acid orally, increased degenerations of the parenchymal cells in the kidney and heart, comparing with initial stadium, was noted. But, the similar vascular damages were observed in the organs especially in the liver and spleen. Moreover, the lymphatic spaces have been dilated progressively, and some serous exudates was seen in the lymphatic spaces of the liver on the 6 th day. 3. In the cases given daily 0.05% arsenious acid orally. nodules accompanied with diffuse infiltration of round cells were observed on the 6 th day. On the 7 th to 8 th day, there appeared coagulation necrosis in which central areas were almost full of polymorphnucleous leucocytes, stelliform cells and degenerative products from the liver cells. Small necrosis composed of lymphocytes and stelliform cells was seen on the 9 th to 10 th days. 4. As the histological changes of the mouse organs described above, were quite similar to those of the infectious hepatitis cases, this study would offer some suggestions to clarify the contributing factors in the pathology of infectious hepatitis.
Published Date
1960-01-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume72
Issue
issue2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
545
End Page
552
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/72/2/72_2_545/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma