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ID 18434
Eprint ID
18434
FullText URL
77_1495.pdf 5.13 MB
Title Alternative
Studies On the Effects of Cytochrome C On the Hematopoiesis of Bone Marrow Part 2 Effects of Cytochrome C On Leukopoietic Functions By Means of Bone Marrow Tissue Cuiture Supplement: Clinical Application of Cytochrome C to Some Hematological Disorder
Author
Makihata, Tadashi
Abstract
By means of bone marrow tissue culture the author investigated the effects of cytochrome C on leukopoietic function and obtained the following results: 1) When cytochrome C was added directly to the bone marrow tissue culture of normal guinea pigs, normal persons and patients with various diseases the growthrate of outgrowth, the wandering velocity and carbon particle phagocytosis of neutrophils were increased as compared with those of the control added with saline. As the result, it has been seen that by adding an optimal amount of cytochrome C the leukopoietic functions of bone marrow were accelerated. 2) When cytochrome C was added with carcinostatic substances to the bone marrow tissue culture of normal persons, the growth rate of outgrowth, the wandering velocity and the carbon-particle phagocytosis of neutrophils were increased as compared with those of the control added with only carcinostatic substances. The similar results were obtained in the case of bone marrow tissue culture of guinea pigs of which bone marrow had been made hypoplastic by repeated administration of carcinostatic substauces and then injected with the repeated administration of cytochrome C. On the other hand, in its clinical applications, the repeated administration of cytochrome C were effective on some cases of leukopenia induced with carcinostatic substances. As it has been demonstrated that cytochrome C has some relieviug effects on the disturbance of leukopoietic functions of bone marrow successively injected with carcinostatic substances.
Published Date
1965-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume77
Issue
issue10-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1495
End Page
1510
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/77/10-12/77_10-12_1495/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma