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ID 18377
Eprint ID
18377
FullText URL
Thumnail 77_1245.pdf 1.2 MB
Title Alternative
Studies on Treatment of Bronchial Asthma with Chloroquine and it's Pharmacological Actions Part. 2. Studies on Mechanism of Action of Chloroquine in Treatment of Bronchial Asthma
Author
Moritani, Yoshiaki
Abstract
In order to clarify the mechanism of action of chloroquine, pharmacological actions of the drug were studied in the resected intestine of guinea pig, inflammatory edema caused on the paw of rat and passive cutaneous anaphylaxis in guinea pig. 1) In the study of the resected intestine of guinea pig, anti-histamine action of chloroquine was noted by showing that the drug had complete antagonistic action against the intestinal contraction caused by histamine administration. While chloroquine did not show anti-serotonine action; contraction of the intestine by serotonine was not influenced at all by the drug administration. 2) In the study of making inflammatory edema on the paw of rat, chloroquine showed inhibitory effect to the edema caused by histamine administration. However, the drug showed scarcely inhibitory effect to the serotonine and dextran edema. Other signs of antinflammatory effct of chloroqine was demonstrated by such finding that remarkable anti-inflammatory inhibition was revealed by the drug administration to the edema caused by anti-serum allergic inflammation. 3) Furthermore, chloroquine showed marked anti-allergic action on passive cutaneous anaphylaxis of guinea pig. Above mentioned pharmacological actions of chloroquine such as anti-histamine, anti-inflammatory and anti-allergic action as well as other actions of chloroquine such as relaxation of the smooth muscle, fibroblast-inhibiting action, inactivity of the antibody or improvement of general constitution are thought to be very important mechanism of actions to the treatment of bronchial asthma.
Published Date
1965-09-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume77
Issue
issue8-9
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1245
End Page
1256
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/77/8-9/77_8-9_1245/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma