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ID 17589
Eprint ID
17589
FullText URL
Thumnail 85_331.pdf 2.3 MB
Title Alternative
Clinical Studies on Serum Glycoproteins in Patients with Malignant Neoplasm Part Ⅰ. Relationship between degree of progression of the diseases and serum α(1)-acid glycoprotein and α(1)-antitrypsin
Author
Onoshi, Taisuke
Abstract
Serum α(1)-acid glycoprotein (α(1)-AG) and α(1)-antitrypsin (α(1)-AT) levels were measured in 30 controls, 57 patients with nonmalignant disease and 249 patients with malignant neoplasm of various sites and stages. An almost parallel increase of these glycoproteins was observed in patients with advanced cancer except hepatoma, but in cases with localized lesion these serum levels remained normal. In 85 patients with lung cancer and 49 with stomach cancer, considerable relationship was observed between the serum levels of these glycoproteins and degree of progression of cancerous lesions. Therefore, it seems that these glycoprotein levels are a relible index for staging malignant diseases. In Hodgkin's disease, however, there was no relationship between these serum levels and its clinical stage, but these glycoprotein levels in B cases of Hodgkin's disease were significantly elevated than in A cases. Evaluation of these glycoproteins would serve as a diagnostic means in patients with hepatomegaly and/or jaundice, since in patients with hepatoma α(1)-AG levels are decreased and α(1)-AT levels are elevated, in patients with metastatic liver cancer both of them are significantly elevated and in cirrhosis of the liver α(1)-AG levels are clearly decreased and α(1)-AT levels remain normal.
Published Date
1973-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume85
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
331
End Page
348
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/85/7-8/85_7-8_331/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma