このエントリーをはてなブックマークに追加
ID 17464
Eprint ID
17464
FullText URL
Thumnail 87_737.pdf 515 KB
Title Alternative
Studies on fecal bilirubinoid. Part 1. Influence on antituberuculosis drugs on fecal bilirubinoid in lung tuberuculosis
Author
Seo, Kenji
Abstract
To elucidate the influences on the intestinal fecal flora by antituberuculosis drug rifampicin and the combination with other remedies to tuberuculosis, fecal bilirubinoids were fractionated by IMAI's column chromatography, and identified with photochemical natures of them. Examined cases with lung tuberuculosis were consisted of two groups (A) five cases were administered rifampicin (RFP) only, (B) fifteen cases were given RFP and other antituberuculosis drugs, and (C) five normal subjects as control. The results were as follows: 1) After administration of antituberuculosis drugs, the amount of fecal urobilinogen decreased significantly from 198.44mg to 118.63mg averaged daily. 2) No significant change was observed in the results of liver function tests, that is, serum bilirubin, nonspecific colloid reactions, GOT, GPT, cholesterol, alkaline phosphatase and triglyceride before and after medication. 3) Mesobilirubin and dihydromesobilirubin were identified in each two cases out of group A and group B. Mesobilirubin was detected in two cases out of four using first choice remedies to lung tuberuculosis and a case administered Kanamycin, INH and ethambutol. 4) Absorption maxima of the chloroform fraction colored yellow extracted from the feces of group A were not observed in group C. The yellow pigment did not identified as bilirubinoid or rifampicin and its derivatives with absorption spectra and chemical reactions for the bile pigments. 5) The intermediates of bilirubin to urobilinogen were identified in group A and group B, these results support RFP influences on the intestinal fecal flora from the point of bilirubin metabolism in the intestine.
Published Date
1975-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume87
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
737
End Page
747
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/87/9-10/87_9-10_737/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma