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ID 17423
Eprint ID
17423
FullText URL
90_969.pdf 2.22 MB
Title Alternative
Aging and sensitivity of rat granulation tissue and thymus to glucocorticoids
Author
Fujiwara, Ryoichi
Saeki, Kiyomi
Tomita, Seiichiro
Abstract
Granulomas were induced in rats of both sexes at different weeks of age by subcutaneous implantation of formalin-soaked filter-paper disks. The sensitivity changes with aging to the antigranuloma and thymolytic actions of prednisolone acetate were studied by measuring the dry-defatted weight of granulomas and the wet weight of thymus. The prednisolone acetate effects on these tissues were also investigated by electron microscopy. In male rats, the amount of granulation tissue increased from 6 to 12 weeks of age; but no difference in granuloma weight was evident between the 12- and 20-week-old groups. In females, the granuloma weight also increased form 6 to 8 weeks. However, heavier granulomas were found in males than in females. In both sexes, the 20-week-old group showed lower sensitivity to the antigranuloma and thymolytic actions of prednisolone acetate than the 6- and 8-week-old groups. In the 6-, 8-and 20-week-old groups of both sexes, marked differences were not found between the antigranuloma potency and thymolytic potency of prednisolone acetate. The prednisolone acetate dose required to produce appreciable electron microscopic changes were about the same in granulation tissue and thymus. The present results show that rat granulation tissue and thymus have similar degrees of sensitivity to glucocorticoids and that the sensitivity of these tissues is lowered with aging.
Published Date
1978-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume90
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
969
End Page
979
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/90/7-8/90_7-8_969/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma