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ID 17014
Eprint ID
17014
FullText URL
Thumnail 91_1467.pdf 303 KB
Title Alternative
The influence of cadmium on adenine nucleotide concentration and the effect of lanthanium on K(+)-release of rat liver mitochondria induced by cadmium
Author
Nogami, Yusaku
Abstract
The influence of cadmium (Cd(2+)) on adenine nucleotide concentration in a reaction mixture consisting of rat liver mitochondria and ADP was studied using high performance liquid chromatography. The results were as follows: An increase in AMP concentration was brought about by the addition of Cd(2+). This increase in AMP concentration occurred in parallel with increase in Cd(2+) concentration. The appearance of AMP was thought to be due to an ATPase reaction and an adenylate kinase reaction stimulated by Cd(2+) although further studies on the adenylate kinase reaction stimulated by Cd(2+) are needed. An increase in AMP may influence metabolism via glycolysis. As lanthanium (La(3+)) is related to Ca(2+)-binding sites, the effect of La(3+) on the K(+)-release of rat liver mitochondria induced by Cd(2+) was also studied. The results were: K(+)-release induced by Cd(2+) was inhibited by La(3+). The Cd(2+)-binding site was thought to be related to the Ca(2+) carrier of mitochondria.
Keywords
ミトコンドリア
ヌクレオタイド
カドミウム
K(+)-遊出
ランタン
Published Date
1979-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1467
End Page
1473
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/11-12/91_11-12_1467/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma