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ID 16947
Eprint ID
16947
FullText URL
94_1009.pdf 810 KB
Title Alternative
Adjuvant therapy of metastatic tumor after excision of main tumor Effect of preoperative intratumoral administration of immunostimulant OK-432 and splenectomy on metastatic tumor
Author
Hatozaki, Akikazu
Abstract
The acceleration of metastasis after excision of the main malignant tumor and the worsening of the prognosis are sometimes experienced. This phenomenon was simulated in model experiments using Lewis lung carcinoma (3LL) cells and BDF(1) mice. The change of cell-mediated immunity was also studied using delayed type hypersensitivity (DTH) skin reaction. For the purpose of getting a better prognosis, preoperative intratumoral administration of large doses of the immunostimulant OK-432 and splenectomy were studied as possible adjuvant therapy to surgical treatment. Pulmonary metastases and their growth were accelerated after excision of the main subcutaneous tumor, and as a result survival time was not extended. However, DTH increased after the operation. Splenectomy in the early stage was significantly effective on survival, increase of DTH and growthinhibition of the main tumor. The optimum dose of OK-432 in intratumoral administration was 10KE/mouse, and a significant effect was obtained on survival, increase of DTH and growth-inhibition of the main tumor with this dose. Preoperative intratumoral administration of OK-432 and splenectomy in the early stage were useful adjuvant therapy to surgical treatment. A significant effect was obtained on suppression of pulmonary metastases, increase of DTH and survival.
Keywords
補助療法
摘脾
OK-432
術前腫瘍内投与
delayed type hypersensitivity
Published Date
1982-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume94
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1009
End Page
1022
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/94/11-12/94_11-12_1009/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma