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ID 16820
Eprint ID
16820
FullText URL
Thumnail 91_355.pdf 2.55 MB
Title Alternative
Effects of extracorporeal circulation on myocardial metabolism and postoperative cardiac function
Author
Hara, Kouhei
Abstract
The experiment was carried out to investigate myocardial metabolism during extracorporeal circulation (ECC) and cardiac function following open heart surgery. Myocardial changes were assessed by measuring the levels of cyclic AMP, ATP, lactate and pyruvate in the right atrial myocardium and coronary blood. Myocardial cyclic AMP and ATP decreased significantly during ECC, although they remained with moderate hypothermia. The level of lactate in the myocardium rose in all cases. There was no significant correlation between ECC time and hypothermia. Serum lactate was elevated at the beginning of ECC and increased progressively during ECC, but the coronary A-V difference of lactate (⊿L) remained unchanged. The serum pyruvate level increased moderately during ECC but its A-V difference did not vary. The data suggest that lactate and pyruvate were taken up by the myocardium. There was a significant inverse correlation between cardiac index and ECC time at 2, 4 and 6 hours after operation. Stroke index showed attitude similar to cardiac index. There was a significant positive correlation between total peripheral vascular resistance and ECC time. The cardiac index and total peripheral vascular resistance with hypothermia were significantly better than those with normothermia. Patients with higher myocardial cyclic AMP and ATP at the end of ECC had better cardiac indices at 2 and 6 hours after open heart surgery.
Keywords
体外循環
開心術後心機能
心筋代謝
サイクリックAMP
ATP
Published Date
1979-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
355
End Page
378
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/3-4/91_3-4_355/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma