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ID 16637
Eprint ID
16637
FullText URL
Thumnail 93_739.pdf 1010 KB
Title Alternative
Studies on antitumor activity of interferon 1. Effect of interferon on human hematopoietic cell lines grown in vitro
Author
Lai, Miinyuh
Abstract
A total of 12 hematopoietic cell lines was tested for in vitro sensitivity to interferon (IF). The cell lines were 4 T-cell ALL lines (TALL-1, MOLT-4, HPB-ALL, HSB-2), 1 ATL line (MT-1), 2 null-cell ALL lines (NALL-1, KOPN-8), 1 pre-B-cell ALL line (NALM-18), 1 B-cell line (BALL-1), 1 myeloma line (Oda), 1 Burkitt lymphoma line (JBL-3) and 1 APL line (HL-60). At a concentration of 1,000 U/ml, all 4 T-cell ALL lines, NALM-18, NALL-1 and Oda showed high or moderate sensitivity to the growth inhibition effect of IF. BALL-1 showed slight sensitvity and its in vitro growth was considerably inhibited at a higher concentration of IF (5,000 U/ml). However, MT-1, JBL-3, KOPN-8 and HL-60 were resistant to IF and their in vitro growth was not inhibited at all even at the concentration of 1,000 U/ml. MT-1 cells, although resistant to IF in suspension culture, were sensitive in agar culture. Colony formation was markedly inhibited at a concentration of 1,000 U/ml. The mechanism of growth inhibition by IF and the implications of the present findings are discussed.
Keywords
Interferon
Antitumor activity
Hematopoietic
cell lines
Published Date
1981-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume93
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
739
End Page
748
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/93/7-8/93_7-8_739/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma