このエントリーをはてなブックマークに追加
ID 16393
Eprint ID
16393
FullText URL
96_353.pdf 243 KB
Title Alternative
Studies on biochemical effects of manganese Ⅳ; Cooperative effects of manganese and vanadium on the energy transfer reaction of rat liver mitochondria
Author
Morita, Keijiro
Abstract
Cooperative effects of Mn(2+) and V(5+) on the energy transfer reaction of rat liver mitochondria were investigated. Mn(2+) (0.10-0.05mM) increased State 4 resperation and decreased State 3 respiration, indicating an uncoupling action on the mitochondria. V(5+) alone at the concentration of 0.1-0.8 mM had no noticeable effect on mitochondrial respiration. In the presence of V(5+), Mn decreased both State 3 and State 4 respiration. The degree of the inhibition was extreme in State 3 respiration at a low concentration of Mn. The change from the accelation of State 4 respiration by Mn(2+) alone to its inhibition by Mn(2+) and V(5+) suggests an incease of cleteriovation in mitochondrial function by the cooperative action of Mn(2+) and V(5+). Cooperative effects of Mn(2+) and Mg(2+) on the energy transfer reaction have been described. In the presence of Mg(2+), the uncoupling action of Mn(2+) was not observed, suggesting that the injurious effect of Mn(2+) on mitochondrial membrane was depressed by Mg(2+). However, phosphorylation activity was more strongly inhibited with Mn(2+) and Mg(2+) together than with Mn(2+) alone.
Keywords
ミトコンドリア
酸化的リン酸化
マンガン
バナジウム
マグネシウム
Published Date
1984-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
353
End Page
358
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/3-4/96_3-4_353/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma