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ID 16388
Eprint ID
16388
FullText URL
Thumnail 95_987.pdf 3.84 MB
Title Alternative
Inhibitory action of 4-amino-3(RS)-hydroxybutanoic acid maleate on pentylenetetrazol, bicuculline and penicillin induced seizure discharges in cats
Author
Numoto, Akihiro
Abstract
Effects of 4-amino-3(RS)-hydroxybutanoic acid maleate [(RS)-GABOB maleate] on threshold of pentylenetetrazol (PTZ) induced convulsion in the rabbit, and PTZ, bicuculline or penicillin induced seizure discharges in cats were examined and found following results; An intravenous (i.v.) injection of (RS)-GABOB maleate increased the threshold of convulsion, and an intracisternal (i.c.) injection of it prolonged latency for onset of spike discharges and decreased frequency and duration of the burst. The i.c. injection of (RS)-GABOB maleate apparently inhibited the both bicuculline and penicillin induced seizure discharges and the i.v. injection slightly depressed them. An injection of (RS)-GABOB maleate into the reticular formation absolutely inhibited the penicillin induced seizure discharges. The inhibitory action of (RS)-GABOB maleate on the penicillin induced abnormal discharges was stronger than that of (R)-GABOB.
Keywords
4-Amino-3(RS)-hydroxybutanoic acid maleate
ぺンチレンテトラゾール
ぺニシリン
ビククリン
Published Date
1983-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
987
End Page
1001
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/9-10/95_9-10_987/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma