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ID 16371
Eprint ID
16371
FullText URL
Thumnail 95_881.pdf 456 KB
Title Alternative
Studies on macrophage function in in vitro immune response Part 2. Functional analysis of macrophage from patients with systemic lupus erythematosus.
Author
Shinohara, Yoshitoshi
Abstract
To analyse the function of macrophages (MΦ) from systemic lupus erythematosus (SLE) patients, spontaneous IgG synthesis, PWM-induced IgG production and Staphylococcal phage lysate (SPL)-induced DNA synthesis by MΦ depleted mononuclear cell (MNC) fraction or unfractionated MNC were examined. The depletion of MΦ enhanced the spontaneous IgG synthesis reaction in inactive SLE, but reduced it in active SLE. The depletion of MΦ restored the ability of SLE MNC to respond to PWM, although the IgG production by unfractionated MNC was suppressed by the addition of PWM. The presence of normal or SLE 10% MΦ enhanced SPL-induced DNA synthesis, but the enhancement obtained by SLE MΦ was less than that obtained by normal MΦ. These results suggest that in inactive SLE, MΦ may show a suppressive effect on spontaneous B cell hyperactivity, but in active SLE, MΦ may loose this effect and/or reveal an enhancing effect. SLE MΦ seem to suppress the PWM-induced IgG synthesis reaction by SLE MNC in the presence of PWM. In addition, SLE MΦ have certain functional defects in promoting SPL-induced DNA synthesis.
Keywords
systemic lupus erythematosus
macrophage
spontaneous IgG synthesis
PWM-induced IgG synthesis
(3)H-thymidine incorporation
Published Date
1983-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
881
End Page
889
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/9-10/95_9-10_881/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma