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ID 16357
Eprint ID
16357
FullText URL
95_767.pdf 732 KB
Title Alternative
Immunochemotherapy of Gastric Cancer with OK-432 Discussion of the immunological parameters and survival rate in relation to prognosis
Author
Moriyasu, Fumiaki
Abstract
A Streptococcal preparation, OK-432, has been used for the treatment of cancer patients as a non-specific immunostimulant. According to the reports of many investigators, MFC (Mitomycin C, 5-Fluorouracil, Cytosine arabinoside) chemotherapy was effective in gastric cancer. Therefore, in this surdy, 77 gastric cancer patient were treated with OK-432 in combination with MFC chemotherapy. Immunological parameters, such as lymphocyte counts, T-cell counts, PHA blastformation rate and the PPD skin test, and the survival rate were examined to determine which was suitable for establishing the prognosis of cancer patients. The immunochemotherapy with OK-432 combined with MFC chemotherapy was effective in Stage III and Stage IV gastric cancer patients. Treatment with OK-432 prevented the depression of cell-mediated immunity induced by surgical intervention and administration anti-cancer agents. The immunotherapy with OK-432 enhanced the cell-mediated immunity of gastric cancer patients for 3 to 12 months after operation. However, elevation of the cell-mediated immunity was not detected more than 12 months after operation. It seemed that the immune status indicated by more than 3 out of the 4 immunological parameters reflected the cell-mediated immunity of gastric cancer patients. Moreover there was a statistically significant correlation between prognosis and the immune status of the patients. The long term prognosis of gastric cancer patients could be estimated by the values of the immunological parameters 3 months after operation. Neither over stimulation nor severe side effects were noted after long term administration of OK-432 to gastric cancer patients, and OK-432 seemed to be safe for use.
Keywords
胃癌
OK-432
MFC療法
免疫学的パラメーター
予後
Published Date
1983-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
767
End Page
781
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/7-8/95_7-8_767/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma