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ID 16347
Eprint ID
16347
FullText URL
95_701.pdf 378 KB
Title Alternative
Studies on adult T-cell leukemia(ATL) II. Terminal deoxynucleotidyl transferase(TdT) and monoclonal antibody defined T-cell differentiation antigens of ATL cells
Author
Sogawa, Jujiro
Abstract
TdT and surface T-cell antigens of leukemic cells from 14 patients with ATL were analysed with a TdT immunofluorescent assay kit(BRL) and monoclonal antibodies (Becton-Dickinson, Leu-1, Leu-2a and Leu-3a antibodies). The TdT assay kit and the monoclonal antibodies were tested to confirm their specificities using various types of cultured cell lines and fresh hematopoietic malignant cells. The reactivities of the kit and antibodies were consistent with the previously reported specificities. TdT activity in leukemic cells from 6 out of 7 ATL patients was not detected; however, cells from one patient did contain weak TdT activity. The majority of the ATL cells reacted with Leu-1 and Leu-3a antibodies but not with Leu-2a. The lack of or weak TdT activity and the expression of Leu-1 and Leu-3a reactive T-cell antigens of ATL cells indicate that ATL cells are of mature and helper/inducer T-cell origin.
Keywords
Adult T-cell leukemia
TdT
Monoclonal antibody
Helper/inducer T-cell
Published Date
1983-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
701
End Page
709
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/7-8/95_7-8_701/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma