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ID 16342
Eprint ID
16342
FullText URL
95_665.pdf 4.57 MB
Title Alternative
Measurement of circulating immune complexes using Fc receptors on guinea pig peritoneal exudate cells. Part 2. Measurement of circulating immune complexes in patients with systemic lupus erythematosus, rheumatoid arthritis and thyroid diseases.
Author
Saito, Yoshihito
Abstract
Circulating immune complexes have been detected in patients with systemic lupus erythematosus(SLE), rheumatoid arthritis(RA), Graves' disease and Hashimoto's disease by a newly established method using guinea pig peritoneal exudate cells. This method discriminated 75.0% of the SLE, 72.4% of the RA, 50.0% of the Graves' disease and 40.0% of the Hashimoto's disease patients from normal controls. IC levels correlated significantly with CH50, slightly with anti DNA antibody, but with neither the ANF staining pattern nor the degree of renal damage assessed by FAT findings in SLE patients. No correlation was observed between disease activity and IC levels in patients with RA. Elevated levels of IC were detected in some patients with thyroid disease by this method, but not by the Clq solid phase enzyme immunoassay. Serum fractionation with a Sepharose 6B column revealed that the molecular weight of the substance which this method can detect is larger than 19S. This method is not interfered with by γ-globulin nor the rheumatoid factor in serum. This is a simple, sensitive and the only practical method among the methods using Fc receptors.
Keywords
immune complex
guinea pig peritoneal exudate cell
systemic lupus erythematosus
rheumatoid arthritis
thyroid diseases
Published Date
1983-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
665
End Page
676
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/7-8/95_7-8_665/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma