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ID 16339
Eprint ID
16339
FullText URL
95_643.pdf 438 KB
Title Alternative
Studies on antigens of a leukemic null-cell line (NALL-1)II. A leukemia-lymphoma associated antigen detected by rabbit anti-NALL-1 serum.
Author
Uno, Junzaburo
Abstract
Rabbit antiserum was raised against leukemic null-cell line, NALL-1. After absorptions with normal human red blood cells, normal human liver cells and established leukemic T-cells (TALL-1) and B-cells (BALL-1), the antiserum reacted specifically with leukemic null-cell lines (NALL-1, KOPN-1, KOPN-8 and AL-6), but not with cells of TALL-1, BALL-1 and an acute promyelocytic leukemic cell line (HL-60). This absorbed anti-NALL-1 serum also reacted with 9 out of 12 null-acute lymphoblastic leukemia cells, 4 of 10 chronic myelogenous leukemia cells in blastic crisis and 2 of 4 null-non-Hodgkin's lymphoma cells, but not with other leukemic cells. The reactivities of the antiserum against normal peripheral blood mononuclear cells and PHA-stimulated blasts were less than 5%. These results indicate that the antigen defined by the absorbed anti-NALL-1 serum is a null-cell type leukemia-lymphoma associated antigen, but not a specific one. Thus the antiserum is a useful marker for the diagosis of null-cell type leukemia and lymphoma.
Keywords
Null-cell白血病細胞株(NALL-1)
白血病関連抗原
家兎抗ALL血清
Published Date
1983-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
643
End Page
652
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/7-8/95_7-8_643/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma