このエントリーをはてなブックマークに追加
ID 16335
Eprint ID
16335
FullText URL
95_623.pdf 656 KB
Title Alternative
The metabolism of L-(amidino-(15)N)-arginine to guanidino compounds.
Author
Shindo, Shoichiro
Abstract
The metabolism of guanidino compounds was determined by analysing the incorporation of (15)N from L-(amidino-(15)N)-arginine ((15)N-ARG) into guanidino compounds. (15)N enrichment of guanidino compounds in the plasma, brain, kidney and liver was determined spectroscopically. (15)N-ARG administered intraperitoneally to mice was rapidly distributed to the plasma, kidney and liver, but was highly diluted by ordinary arginine (ARG) in both the plasma and organs. It was found that the rate of uptake of (15)N-ARG into the brain was slower than into the kidney or liver, which suggests that ARG could not pass easily through, or was regulated by the blood-brain barrier. It was also found that (15)N-ARG was metabolized mainly to guanidinoacetic acid (GAA) in the kidney and to urea in the liver. It was further suggested that creatine was synthesized actively in the liver from GAA which was synthesized in the kidney, and then creatine was distributed to the plasma and other organs. The (15)N of (15)N-ARG was incorporated significantly into guanidinosuccinic acid (GSA) and methylguanidine (MG), which indicates that ARG is involved in the synthesis of MG and GSA. MG might be synthesized directly from ARG in the liver, because (15)N in MG was significant 1 min after (15)N-ARG administration. (15)N, however, was not incorporated significantly into guanidinopropionic acid and guanidinobutyric acid.
Keywords
L-[amidino-(15)N]-arginine
グアニジノ化合物
発光分光法
Published Date
1983-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
623
End Page
635
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/7-8/95_7-8_623/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma