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ID 16277
Eprint ID
16277
FullText URL
Thumnail 95_253.pdf 461 KB
Title Alternative
Studies on peripheral monocytes in diabetes mellitus. Part I. Monocyte chemotaxis in diabetes mellitus.
Author
Miyahara, Kiyoshi
Abstract
Chemotaxis of diabetic monocytes was studied. The use of 0.25 x 10(6) monocytes, 20% Zymosan activated serum and incubation at 37℃ for 90 minutes were found to be the optimal assay conditions for the Boyden chamber method using a nuclepore filter. Under these conditions, monocyte chemotaxis was tested in 48 diabetics and 27 normal controls. The results were as follows: 1) Diabetics had low monocyte chemotaxis, especially in aged patients. The normal controls showed no difference with aging. 2) Poorly controlled diabetics showed significantly lower chemotaxis than both normal controls(P<0.005) and good controlled diabetics(P<0.05). The mean values were 40.1±32.4, 71.3±29.9 and 61.4±36.2 monocytes/HPF, respectively. 3) There was no difference in monocyte chemotaxis between diabetic groups treated with diet alone, oral agents or insulin. 4) Six of nine poorly controlled diabetics showed increased monocyte chemotaxis after being good controlled with insulin.
Keywords
糖尿病 (diabetes mellitus)
単球 (monocyte)
走性 (chemotaxis)
Published Date
1983-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
253
End Page
262
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/3-4/95_3-4_253/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma