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ID 16259
Eprint ID
16259
FullText URL
96_313.pdf 566 KB
Title Alternative
Analysis of guanidino compounds in human cerebrospinal fluid. -Guanidinoethanesulfonic acid is observed in some epileptics-
Author
Fujimoto, Noboru
Abstract
Guanidino compounds in cerebrospinal fluid (CSF) of nonneurological and epileptic patients were investigated. After separating using high performance liquid chromatography, and reacting with phenanthrenequinone, the compounds were analyzed fluorometrically. Arginine (Arg), creatinine (CRN) and homoarginine (HArg) were found in all subjects. Trace amounts of guanidinosuccinic acid (GSA) and guanidinoacetic acid (GAA) were detected in some subjects regardless of disease state. Positive correlations were noted in females between Arg and CRN levels and age. Serum Arg and HArg levels were related to in urine concentrations, but there was no association between CSF guanidino compound levels and serum levels. Guanidinoethanesulfonic acid (GES) was detected in the CSF of some epileptic patients. This was confirmed by high voltage paper electrophoresis. This finding suggests that GES may relate to epileptic seizure mechanism.
Keywords
グアニジノ化合物
髄液
てんかん
グアニジノエタンスルホン酸
Published Date
1984-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
313
End Page
325
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/3-4/96_3-4_313/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma