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ID 16210
Eprint ID
16210
FullText URL
Thumnail 96_35.pdf 1.15 MB
Title Alternative
Anti-inflammatory effect of Prozime-10 (P-10), a proteolytic enzyme II. Anti-inflammatory mechanism of P-10 (I)
Author
Maki, Kazuo
Abstract
After intravenous injection of Prozime-10 (P-10) into anesthetized dogs, plasma cortisol rose slowly and reached a maximum 3.5hr or later. With an increase in the dose of P-10 to 10mg/kg, the maximum cortisol concentration increased dose-dependently. When DEP-treated P-10 was injected, a similar release of cortisol occurred but much less prominently than that induced by a corresponding dogs of non-treated P-10. When slices of the dog adrenal cortex were exposed to P-10, no significant release of cortisol was noticed, although ACTH released cortisol markedly. When P-10 was injected (i.v.), a transient but significant increase in plasma histamine (Hi) was noticed. When the sliced tissues were exposed to various concentrations of Hi, cortisol output increased along with an increase in Hi concentration. It became evident that the cortisol release from the sliced tissues due to Hi was provoked via H(1) receptors.
Keywords
蛋白分解酵素
犬副腎皮質
ACTH遊離
コルチゾール
ヒスタミン遊離
Published Date
1984-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
35
End Page
47
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/1-2/96_1-2_35/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma