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ID 16016
Eprint ID
16016
FullText URL
Thumnail 99_1205.pdf 1.36 MB
Title Alternative
Studies on respiratory diseases by bronchoalveolar lavage fluid Part 1. Estimation of immunoglobulins and histamine in bronchoalveolar lavage fluid
Author
Sudo, Michiyasu
Abstract
Immunoglobulins and histamine were estimated in bronchoalveolar lavage fluid (BALF) of 25 patients with bronchial asthma, 7 patients with hypersensitivity pneumonitis, 8 patients with sarcoidosis and 3 patients with bronchiolitis. In 8 healthy subjects, relation levels of immunoglobulins and histamine in BALF were: IgG/alb ratio, 0.28±0.17 (mg/mg); IgA/alb ratio, 0.19±0.15; IgM/alb ratio, 0.01±0.01; IgE/alb ratio, 0.36±0.29×10(2)(IU/mg), and His/alb ratio, 0.67±0.29 (ng/mg). In asthmatic patients, the relation levels of immunoglobulins and histamine in BALF were: IgG/alb ratio, 0.26±0.21; IgA/alb ratio, 0.11±0.06; IgM/alb ratio, 0.01±0.01; IgE/alb ratio, 0.89±0.99×10(2), and His/alb ratio, 1.38±0.84. These patients showed a moderately higher His/alb ratio than healthy subjects. The increased His/alb ratio was closely related to immediate skin tests and serum IgE levels, especially in atopic patients. An inverse relationship was noted between an elevated IgE/alb ratio and/or His/alb ratio and the degree of peripheral airway obstruction. There was a relationship between an elevated IgG/alb ratio and peripheral airway obstruction, although there was no significant relationship between immunoglobulins/alb and/or His/alb ratios and the results of pulmonary function tests. Somewhat higher IgG/ alb and IgM/alb ratios were found in the patients with hypersensitivity pneumonitis than in the healthy subjects, although significantly higher ratios were not observed in patients with sarcoidosis or bronchiolitis. In conclusion, the estimation of immunoglobulins and histamine in BALF is considered to be useful for the explication of the pathogenic mechanism of bronchial asthma.
Keywords
気管支肺胞洗浄
気管支喘息
免疫グロブリン
ヒスタミン
Published Date
1987-10-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1205
End Page
1221
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/9-10/99_9-10_1205/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma