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ID 15893
Eprint ID
15893
FullText URL
Thumnail 99_337.pdf 424 KB
Title Alternative
Effect of High Fat and High Sugar Diet on Glucose Tolerance, Insulin Response to Glucose Load and Insulin Sensitivity in Rats
Author
Okazaki, Satoru
Abstract
To investigate the precipitating effects of the westernized diet on diabetes mellitus, glucose tolerance and insulin response to oral glucose load (1.5g/kg body weight) and insulin sensitivity to exogenous insulin (0.2U/kg) were studied in rats fed an experimental diet for 8 weeks. Four experimental diets were used : low fat-no sugar diet (energy ratio of 10% fat, 70% starch, a model of the traditional Japanese diet), high fat-high sugar diet (40% fat, 20% starch, 20% sugar, a model of the westernized diet), low fat-high sugar diet (10% fat, 50% starch, 20% sugar) and high fat-no sugar diet (40% fat, 40% starch). In high fat-high sugar diet rats, the body weight increased more, plasma glucose and insulin levels were higher while fasting and after oral glucose load, and insulin sensitivity was lower than in low fat-no sugar diet rats. Similar impaired glucose tolerance and hyperinsulinemia were present both in low fat-high sugar diet rats and in high fat-no sugar diet rats. However, insulin sensitivity was decreased in low fat-high sugar diet rats, but not in high fat-no sugar diet rats. These data indicate that the high fat-high sugar composition of the westernized diet has some precipitating effects on diabetes mellitus and that the diabetogenic mechanisms of the high fat diet and high sugar diet may be different.
Keywords
高脂肪食
高砂糖食
耐糖能
インスリン
インスリン感受性
Published Date
1987-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
337
End Page
345
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/3-4/99_3-4_337/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma