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ID 15877
Eprint ID
15877
FullText URL
Thumnail 99_213.pdf 1.19 MB
Title Alternative
Morphological and pathological study of malformed ears in mouse and rat fetuses using combined staining of bone and cartilage
Author
Naito, Masayuki
Abstract
Pregnant ddN mice were injected intraperitoneally with 15,000 IU of water-miscible vitamin A on the eighth day of pregnancy, and fetuses were removed from the mice on the eighteenth day. Pregnant Wistar rats were injected intraperitoneally with 200,000 IU per kg body weight of water-miscible vitamin A on the tenth day of pregnancy, and fetuses were removed from the rats on the twenty-first day. The pathological changes of the malformed ears of the mouse and rat fetuses were observed by stereoscopic microscopy after combined staining of bone and cartilage. The incus, stapes and Reichert's cartilage all were malformed or absent in most of the mouse ears, much more than in the rat ears. The malleus and Meckel's cartilage were normally shaped in most of the ears of both animals. The author concluded that a considerable part of the incus is derived or originated from the second arch cartilage and that the malleus is derived entirely from the first arch cartilage.
Keywords
hypervitaminosis A
mouse fetus
malformed ossicles
Published Date
1987-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
213
End Page
220
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/3-4/99_3-4_213/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma