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ID 14535
Eprint ID
14535
FullText URL
Thumnail 103_373.pdf 712 KB
Title Alternative
Clinical study on idiopathic thrombocytopenic purpura (ITP) Part 2. Analysis of the treatment of ITP and the value of colchicine therapy for the steroid resistant ITP
Author
Tsurumi, Naokazu
Abstract
Clinical effects of steroid and colchicine therapy in 49 patients with ITP especially the refractory cases were evaluated in comparison with splenectomy and danazol therapy. There were 27(55%) steroid resistant patients who could not maintain platelet counts of 5×10(4)/μl with prednisolone doses of less than 10mg/day. Among the 16 steroid resistant patients treated with colchicine, there were 3 patients with complete remission and 3 others who had good to excellent response, that is, 6(37.5%) improved overall. This therapy was more effective than splenectomy (33.3%) and danazol (25%). Colchicine was did not effective in patients who did not respond to prednisolone, but was useful when patients showed at least a transient rise of the platelet count with prednisolone. In many cases, a response to colchicine was seen after a month, and in the patients who failed to show a rise in the platelet count after 2 months of colchicine therapy, no benefit was seen even when the therapy was continued. Colchicine is advantageous in the treatment of the steroid resistant ITP over the immunosuppressive agents or high-dose γ-globulin that are expensive and produce only a transient rise in the platelet count.
Keywords
steroid resistant ITP
colchicine
danazol
splenectomy
Note
原著
Published Date
1991
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
373
End Page
386
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/103/4/103_4_373/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma