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ID 14533
Eprint ID
14533
FullText URL
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Title Alternative
Clinical study on idiopathic thrombocytopenic purpura (ITP) Part 1. The relationship between the platelet associated IgG(PAIgG) level and the prognosis of idiopathic thrombocytopenic purpura (ITP)
Author
Tsurumi, Naokazu
Abstract
Platelet associated IgG (PAIgG) levels in 45 ITP patients were measured by the single radialimmunodiffusion (SRID) technique to determine whether PAIgG could be used as a prgnostic index for ITP. The PAIgG levels in ITP patients were significantly higher than those in normal controls and showed an inverse correlation with the platelet count (Y221.9-13.4X,p<0.01). The PAIgG level decreased significantly after the first course of steroid therapy in both the steroid responsive and the steroid resistant ITP patients. However, in the clinically stable period, the PAIgG level in the steroid resistant patients remainde significantly higher than in the responsive patients (p<0.005). Although the PAIgG level after splenectomy decreased significantly(p<0.05) in the patients with complete remission, it remained remained significantly higher (p<0.05)in the nonresponders. Maximum platelet count after therapy divided by the number of days elapsing from the time of therapy to the day showing the maximum platelet count, was significantly higher in the responders. The PAIgG level in the stable period after steroid therapy, and the rate of increase in the platelet counts in the early period after steroid therapy were suggested to be useful as indices of the prognosis of ITP.
Keywords
ITP
refractory ITP
PAIgG
Note
原著
Published Date
1991
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
359
End Page
371
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/103/4/103_4_359/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
References
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language
日本語
Copyright Holders
岡山医学会
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publisher
Refereed
True
Eprints Journal Name
joma