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ID 14523
Eprint ID
14523
FullText URL
Thumnail 103_315.pdf 548 KB
Title Alternative
The metabolism of methyl isobtyl ketone and its biological monitoring Part 1. Qualitative and quantitative studies of methyl isobtyl ketone exhaled from the lungs and excreted in the urine, and the metabolites in the urine of rats injected with methyl isobutyl ketone
Author
Hirota, Naomasa
Abstract
Rats were injected intraperitoneally with 100mg/kg, 200mg/kg and 300mg/kg of methyl isobutyl ketone (MIBK) in a single dose, and the amount of MIBK in the expired air and in the urine were studied. One of the metabolites was identified as 4-methyl-2-pentanol (4M2P) in the urine by gas chromatography-mass spectrometry. The concentration of MIBK in the exhaled air attainend its maximum within 0.5 hour. Thereafter it decreased with a half life of 0.6 hour, and 41.1±8.7 (m±SD) % of the total amount injected was exhaled within 24 hours. The concentration of MIBK in the urine attained its maximum within 3 hours after injection. Then it decreased with a half life of 1.8 hours and 0.19±0.11 (m±SD) % of the total amount administered was excreted in 18 hours. The concentration of 4M2P in the urine attained its maximum in 3-6 hour and decreased gradually thereafter. Its half life was 3.2 hours and 0.31±0.18 (m±SD) % of the total amount was excreted in 12 hours.
Keywords
MIBK
尿中代謝産物
4-メチル-2-ペンタノール
メチルイソブチルケトン
ラット腹腔内投与
Note
原著
Published Date
1991
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
315
End Page
325
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/103/4/103_4_315/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
References
1) Inoue T, Takeuchi Y, et al. : A Nationwide Survey on Organic Solvent Components in Various Solvent products : Part 1. Homoggeneous Products Such as Thinner, Degreasers and Reagents. Ind Health (1983) 21, 175-183.
2) 環境科学辞典,荒木 峻,沼田 眞,和田 攻編,東京化学同人,東京(1985)pp778
3) Smyth, Jr HF, Carpenter CP, and Weil CS, : Range Finding Toxicity Data : List W. Arch Ind Hyg Occup Med (1951) 4, 119-122.
4) Krasavage WJ, O'donghue JL, and DiVincenzo GD, : Patty's Industrial Hygiene and Toxicology, 3rd, ed., Wiley, New York (1982) pp4747-4800.
5) MacEwen JD, Vernot EH, and Haun CC. : Effects of 90-day Continuous Exposure to Methyl isobutyl Ketone on Dogs, Monkeys, and Rats, : U.S. Nat. Thch. Info. Serv., AD Rep ; (1971) ISS #7 30291.
6) Spencer PS and Schaumberg HH : feline Nervous System Response to Chronic Intocxication with Grades of Methyl n-Butyl Ketone, Methyl isoButyl Ketone, and Methyl Ethyl Ketone. Toxicol Appl Pharmacol (1976) 37, 301-311.
7) 産業中毒便覧,第2版,医歯薬出版,東京(1981)pp867-868.
8) May J, : Oder Thresholds of Solvents for Evaluating Solvent Oder in Air : Staub, (1966) 26, 385.
9) Ameri G, Linari F, and Martorano G, : Rilievi Clinici ed Ematochimici in Operai Esposti All'azione di un Chetone Superiore (MIBK) Ripetuti a Distanza di 5 anni. Lav. Um., (1968) 20, 418-423.
10) Elkins HB, : The Chemistry of Industial Toxicology, 2 nd ed., Wiley, New York (1959) pp119-122.
11) 石油化学工業協会産業衛生委員会:許容濃度提案理由書集,日本産業衛生学会,東京(1990)pp100-101.
12) Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices 1990-1991. American Conference of Governmental Industrial Hygienists, Cincinati, Ohio (1990) pp27.
13) Hjelm EW, Haegberg M, Iregren A, and Loef A : Exposure to methyl isobutyl ketone : toxicokinetics and occurence of irriative and CNS symptoms in man. Int Arch Occup Environ Health (1990) 62, 19-26.
14) DiVincenzo GD, Kaplan CJ, and Dedenas J : Characterization of the Metabolites of Methyl n-Butyl Ketone, Methyl iso-butyl ketone, and Methyl Ethyl Ketone in Guinea Pig Serum and Their Clearance. Toxicol Appl Pharmacol (1976) 36, 511-522.
15) 那須 滋:新ヘッドスぺース法による尿中メタノール,アセトンの定量,産業医学(1983)25,199-200.
16) Stehagen E, Abrahamsson S, and McLafferty FW, : Atras of Mass Spectral Data., Interscience Publishers, New York.
17) Carlsson A : Exposure to toluene. Uptake, distribution and eliminaton in man. Scnad J Work Environ Health (1982) 8, 43-55.
18) Liira J, Riihimaki V, Pfaffli P : Kinetics of methyl ethyl ketone in man : Absorption, distribution and elimination in inhalation exposure. Int Arch Occup Environ Health (1988) 60, 195-200.
19) Haggard HW. et al. : J Ind Hyg Toxicol (1945) 27, 1-14.
20) 神谷次郎:芳香族有機溶剤の生体内運命,第三編トルエン投与ラットにおけるトルエンの血中濃度及び呼気中排泄量の時間変動.岡山医誌(1987)99,1647-1650.
21) Ogata M, Taguchi T, Hirota N, Shimada Y and Nakae S : A Database for Biological Monitoring of Aromatic Solvent ; in Biological Monitoring of Exposure to Industrial Chemicals, V. Fiserova-Bargerova and M. Ogata eds, American Conference of Governmental Industrial Hygienist, Inc. Cincinati, Ohio (1990) pp119-125.
22) Ghittori S, Imbriani M, Pezzagno G and Capodaglio E : The Urinary Concentration of Solvents as a Biological Indicator of Exposure : Proposal for the Biological Equivalent Exposure Limit for Nine Solvents. Am Ind Hyg Assoc J (1987) 48(9), 786-790.
23) Imbriani M, Ghittori S, Pezzagno G and Capodaglio E : Urine/ari Partition Coeficients for Some Industrially Important Substances. G Ital Med Lav (1985) 7, 133-140.
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma