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ID 14507
Eprint ID
14507
FullText URL
Thumnail 103_235.pdf 4.7 MB
Title Alternative
Importance of nonrandomly occurring spontaneous chromosome breakpoints in tumorigenesis of Fanconi anemia
Author
Tsuji, Kazushiro
Abstract
Individuals with Fanconi anemia (FA) are susceptible to acute non-lymphocytic leukemia (ANLL) or hepetocellular carcinoma. To clarify why FA is associated with a specific type of neoplasia, we performed cytogenetic studies on somatic cells established from 4 FA patients, two of whom developed acute myelocytic leukemia (AML). A hypersensitive response to mitomycin C (MMC) was obtained in two patients but non-sensitivity in two patients with AML. Analysis of spontaneous break-points showed that the frequency of breakage in the FA patients was 4 to 5 times higher than in normal controls. Significantly more breakpoints gathered on 1p11 or q11, 1q21, 1q32, 2p11, or q11, 3p14, 3q21, 5q15, 7p11 or q11, 8q22, 9q11-12, 9q13, 11q13, 11q23, 12q13, 12q24 and 17q21 bands. Furthermore, many chromosome rearrangements involving these breakpoints were observed. Most of the breakpoints specific to FA coincided with those seen in the rearrangements of ANLL reported so far. These findings suggest that the nonrandomness of spontaneous breakpoints plays an important role in the tumorigenesis of FA.
Keywords
Fanconi amemia
chromosome breakage
tumorigenesis
acute non-lymphocytic leukemia
fragile site
Note
原著
Published Date
1991
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
235
End Page
246
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/103/4/103_4_235/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
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language
日本語
Copyright Holders
岡山医学会
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publisher
Refereed
True
Eprints Journal Name
joma