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ID 14094
Eprint ID
14094
FullText URL
106_549.pdf 6.83 MB
Title Alternative
Clinical studies on plasma cyclic nucleotide levels in acute leukemia
Author
Nonaka, Kenichi
Abstract
Plasma levels of cyclic nucleotides were measured in 71 patients with acute leukemia [50 patients with acute nonlymphocytic leukemia (ANLL), five patients with hypoplastic leuke-mia, and 16 patients with acute lymphocytic leukemia (ALL)], five patients with myelodysplas-tic syndrome (MDS), and 47 healthy volunteers. The cyclic GMP (c-GMP) level, cyclic AMP (c-AMP) level, and c-AMP/c-GMP ratio in healthy volunteers were 15.74±5.10 pmol/ml, 3.20±1.15 pmol/ml and 5.39±2.18, respectively. In the patients with untreated acute leukemia other than hypoplastic leukemia, c-GMP levels were significantly elevated (ANLL : 11.31±13.61 pmol/ml ; ALL : 10.66±7.23 pmol/ml) and c-AMP/c-GMP ratios were significantly reduced (ANLL : 2.01±1.03 ; ALl : 1.66±1.03). These values normalized at remission, than increased or decreased again with recurrence of the disease. Although patients with MDS showed normal c-GMP levels or c-AMP/c-GMP rations, these values were increased or decreased when progression to acute leukemia occurred. There was correlation between c-GMP levels and peripheral leukocyte counts (r=0.429,p<0.05), plasma c-GMP levels and peripheral leukemic cell counts (r=0.412,p<0.05), c-AMP/c-GMP rations and peripheral leukocyte counts (r=-0.577,p<0.05), c-AMP/c-GMP rations and periph-eral leukemic cell counts (r=-0.512,p<0.05), and c-AMP/c-GMP rations and periph-eral leukemic cell counts (r=-0.512,p<0.05), and c-AMP/c-GMP rations and maximum counts of colonies derived from leukemic blast progenitors (r=-0.996,p<0.01). Since plasma levls of cyclic nucleotides reflect the leukemic cell proliferation, measurement of these nucleotides was considered useful for monitoring leukemic cell volume.
Keywords
血漿 cyclic nucleotides
急性白血病
低形成型白血病
Note
原著
Published Date
1994
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
549
End Page
560
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_549/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma