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ID 14067
Eprint ID
14067
FullText URL
106_473.pdf 523 KB
Title Alternative
A role of ATP-sensitive potassium channel in the ischemic myocardial function
Author
Mizuo, Kouzou
Abstract
To determine role of the ATP-sensitive potassium channel (KATP channel) in myocardial function during myocardial ischemia, we evaluated regional myocardial shortening and myocardial blood flow using a constant, low flow perfusion system in open-chest dogs. Coronary blood flow was decreased to halt the control level by constricting the perfusion line with a constant pressure throughout the experiment. Glibenclamide (G), a KATP channel blocker, and pinacidil (P), a KATP channel opener, was infused into the coronary perfusion line after the flow was reduced. When coronary flow was reduced, coronary perfusion pressure was decreased to 55% of the control value, segmental shortening (% SS) of the subendocarial myocardium from 18±2% to 13±2% (mean ± SEM)(P<0.05) and the subendocardial to subepicardial (endo/epi) blood flow ratio measured with colored micrsphers ranged from 1.17±0.04 to 0.82±0.05(p<0.05). The infusion of G caused further reduction of % SS to 3±1% (P<0.001) without significant change in the endo/epi blood flow ratio. Additional infusion of P improved % SS to 11±2%, which did not significanlty differ from the pre-G value. The fingings strongly strongly suggest that KATP channels participate in maintaining myocardial function during ischemia.
Keywords
ATP-sensitive potassium channel
myocaridial ischemia
regional myocardial function
segment shortening
glibenclamide
Note
原著
Published Date
1994
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
473
End Page
482
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_473/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma