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ID 14051
Eprint ID
14051
FullText URL
106_461.pdf 7.2 MB
Title Alternative
HTLV-Ⅰ infection in patients with pneumoconiosis in regard to complications of malignancy
Author
Sasaki, Takashi
Abstract
The pathogenesis of pneumocniosis following exposure to inorganic dust remains obscure. HTLV-Ⅰ, known as a cause of adult T cell leukemia, has been reported to participate in various interstitial lung diseases. So, HTLV-Ⅰ infection in patients with pneumoconiosis was inves-tigated by detecting anti-HTLV-Ⅰ antibodies by the indirect immunofluorescent methoh and the pX gene by polymerase chain reaction (PCR) and Southern blotting. Furthermore, various malignancies in pneumoconiosis were also analyzed in relation to HTLV-Ⅰ infection. Three of 24 patients (12.5%) demonstrated anti-HTLV-Ⅰ antibodies. Four of 5 patients includ-ing the 3 patients with antibodies demonstrated the pX gene. Various malignant diseases including myelodyspastic syndrome and lung cancer showed a higher incidence in patients with HTLV-Ⅰ infection than in those without HTLV-Ⅰ infection. These findings indicate that HTLV-Ⅰ infection could play an important role in the path-ogenesis of pneumoconiosis and complications of malignancy.
Keywords
塵肺症
HTLV-Ⅰ (human T-lymphotropic virus type Ⅰ)
間接蛍光抗体法
免疫電顕法
PCR (polymerase chain reaction method) 法
Note
原著
Published Date
1994
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
461
End Page
471
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_461/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma