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ID 14024
Eprint ID
14024
FullText URL
Thumnail 105_317.pdf 295 KB
Title Alternative
Hemodialysis membrane with a negative charge : Modeling glomerular basement membrane
Author
Nagake, Yoshio
Abstract
The glomerular basement membrane (GBM) regulates protein permeability by acting as both a size barrier and charge barrier. Since heparan sulfate-proteoglycan (HS-PG) which forms the charge barrier of the GBM contains a sulfonic acid base, we prepared negatively charged membranes by adding a sulfonic acid base to EVAL (ethylene vinyl alcohol) membranes. The permeabilities os the various proteins in these membranes were compared with those of conventional neutrally charged EVAL membranes. The permselectivity for proteins of negatively charged EVAL membranes depends largely upon the interrelation between the pore size of the membranes and size of the proteins. The negatively charged EVAL membranes had a higher selective permeability than the conventional neutrally charged EVAL membranes. Therefore, a negative charge within the dialyzer might produce higher selective permeability than conventional dialyzers.
Keywords
透析膜
腎糸球体基底膜
size barrier
charge barrier
スルホン酸基
Published Date
1993
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
317
End Page
322
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/3-4/105_3-4_317/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma