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ID 14023
Eprint ID
14023
FullText URL
Thumnail 105_303.pdf 1.54 MB
Title Alternative
Orthotopic liver transplantation in dogs : Post-operative changes in plasma-free amino acid levels and the meaning of these changes
Author
Matsuda, Tadakazu
Abstract
To determine the viability of livers after transplantation, three groups of experimental models were prepared (i. e., liver transplantation by the modified Starzl method ; hepatic cold-ischemia with cold ischemic time equal to transplantation time ; and simple laparotomy with sugar loading). Changes in plasma-free amino acid levels were investigated. The results showed an elevation of total amino acid levels in the early stage of a viable liver transplant. In addition, a decrease in the molar ratio of branched chain amino acids and aromatic amino acids was observed during the rejection period. The results also confirmed an increase in ornithine level, NH3, and ornithine carbamyl transferase as well as a decrease in the citrulline level, and unchanged arginine. A disturbance in the reaction in the urea cycle during the second stage was considered the cause. Among the plasma amino acids, alanine showed the greatest increase during the rejection period. This might be attributed to an acceleration in alanine release in the periphery, and an abnormal glucose-alanime cycle. As described above, examining changes in plasma-free amino acid levels may be an effective index of the viability of a liver transplant, both in the early stage and during the rejection poriod.
Keywords
同所性肝移植
血漿中遊離アミノ酸
拒絶反応
尿素回路
Fischer 比
Published Date
1993
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
303
End Page
316
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/3-4/105_3-4_303/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma