ID | 14017 |
Eprint ID | 14017
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FullText URL | |
Title Alternative | Clinical studies on hypoplastic anemia in the aged
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Author |
Ueta, Ikuhiro
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Abstract | To evaluate hypoplastic anemia (HA) in the aged, clinical and hematological findings of 88 patients with HA were analyzed. The patients were classified into 4 groups according to age (Group A : 5-24 y/o, Group B : 25-44 y/o, Group C : 45-64 y/o and Group D : 65 y/o- ). Hematological findings of patients in Group D were also compared to those of aged patients (above 65 y/o) with myelodisplastic syndrome (MDS) to clarify differentiation of HA from MDS. Items studied were severity, therapeutic response, complications, hematological findings, survival period and cause of death. The following results were obtained :
1. HA in the aged was frequently severe.
2. Responses to therapies including anabolic steroids and corticosteroids tended to be poor in the aged compared to those in younger patients.
3. Infections and diabetes mellitus were frequently observed complications in the aged.
4. Mortality in the aged was higher than that in younger patients. 57.1% of the aged died from bleeding.
5. The survival period of patients in Group C and D was shorter than that of patients in Group A and B.
6. Red blood cell count, reticulocytes and hemoglobin level in the aged were significantly lower than those in younger patients. Neutrophil and monocyte counts in the aged tended to be lower than those in younger patients. Nucleated cell counts and percentages of granulocytes and erythroblasts in the marrow were also lower in the aged.
7. The incidence of atypical hematological findings in HA were not different between the aged and younger patients.
8. In a comparison of HA in Group D and MDS in the aged, patients with HA showed severe anemia and thrombocytopenia.
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Keywords | 再生不良性貧血
高齢者貧血
骨髄異形成症候群
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Published Date | 1993
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume105
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Issue | issue3-4
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 265
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End Page | 279
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/105/3-4/105_3-4_265/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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