ID 14017
Eprint ID
FullText URL
Thumnail 105_265.pdf 685 KB
Title Alternative
Clinical studies on hypoplastic anemia in the aged
Ueta, Ikuhiro
To evaluate hypoplastic anemia (HA) in the aged, clinical and hematological findings of 88 patients with HA were analyzed. The patients were classified into 4 groups according to age (Group A : 5-24 y/o, Group B : 25-44 y/o, Group C : 45-64 y/o and Group D : 65 y/o- ). Hematological findings of patients in Group D were also compared to those of aged patients (above 65 y/o) with myelodisplastic syndrome (MDS) to clarify differentiation of HA from MDS. Items studied were severity, therapeutic response, complications, hematological findings, survival period and cause of death. The following results were obtained : 1. HA in the aged was frequently severe. 2. Responses to therapies including anabolic steroids and corticosteroids tended to be poor in the aged compared to those in younger patients. 3. Infections and diabetes mellitus were frequently observed complications in the aged. 4. Mortality in the aged was higher than that in younger patients. 57.1% of the aged died from bleeding. 5. The survival period of patients in Group C and D was shorter than that of patients in Group A and B. 6. Red blood cell count, reticulocytes and hemoglobin level in the aged were significantly lower than those in younger patients. Neutrophil and monocyte counts in the aged tended to be lower than those in younger patients. Nucleated cell counts and percentages of granulocytes and erythroblasts in the marrow were also lower in the aged. 7. The incidence of atypical hematological findings in HA were not different between the aged and younger patients. 8. In a comparison of HA in Group D and MDS in the aged, patients with HA showed severe anemia and thrombocytopenia.
Published Date
Publication Title
Publication Title Alternative
Journal of Okayama Medical Association
Publisher Alternative
Okayama Medical Association
Start Page
End Page
Content Type
Journal Article
Official Url
Related Url
1) 高久史麿:再生不良性貧血の診断基準に関して;昭和48年度業績周 再生不良性貧血Ⅱ,再生不良性貧血の成因と治療,予防に関する研究班(1974)pp205-211.
2) Ehrlich P : Uber einen Fall von Anamie mit Bemerukungen uber regenerative Veranderungen des Knochenmarks. Chrarite-Ann (1888) 13, 300-309.
3) 古宮悦造三:血液疾患の診断及び治療.日内誌(1935)23,143-310.
4) 班長 日比野進 再生不良性貧血の成因と治療,予防に関する研究班:昭和47年度業績集 再生不良性貧血Ⅰ.(1973)pp1-191.
5) 班長 日比野進 再生不良性貧血の成因と治療,予防に関する研究班:昭和48年度業績集 再生不良性貧血Ⅱ.(1974)pp1-402.
6) 班長 日比野進 再生不良性貧血の成因と治療,予防に関する研究班:昭和49年度業績集 再生不良性貧血Ⅲ.(1975)pp1-494.
7) 青木国雄,浜島信之,佐々木信一郎,高久史麿:全国疫学調査結果より見た過去10年間における疫学像と予後の変化;第1表死亡者数,性・年齢(5歳階級)・死因(基本分類)別.昭和47年人口動態統計下巻(1973)118-119.
8) 厚生省大臣官房統計調査部編:第1表死亡者数,性・年齢(5歳階級)・死因(三桁基本分類)別.昭和47年人口動態統計下巻(1973)118-119.
9) 厚生省大臣官房統計調査部編:第1表―1死亡数,性・年齢(5歳階級)・死因(三桁基本分類)別.昭和56年人口動態統計下巻(1982)112-113.
10) 厚生省臣官房統計調査部編:第1表―1死亡数,性・年齢(5歳階級)・死因(三桁基本分類)別.平成元年人口動態統計下巻(1990)112-113.
11) 青木国雄,浜島信之:再生不良性貧血の疫学,血液・腫瘍科(1991)22,58-66.
12) Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralick HR and Sultan C : Proposals for the classification of the myelodysplastic syndromes. Brit J Haematol (1982) 51, 189-199.
13) Frish B and Bartl R : Bone marrow histology in myelodysplastic syndromes. Scand J Haematol (1986) Suppl 45, 21-37.
14) 沖田浩之,高橋 功,竹内 誠,長田 建,関藤典子,林 直樹,青山重夫,稲垣登稔,西村正隆,大本英次郎,依光聖一,木村郁郎,真田 浩,喜多島康一:Myelodysplasia with hypoplastic marrow の検討.臨床血液(1987)28,205-212.
15) 堀田知光,平林憲之,内海 真,滝田資也,山田英雄:再生不良性貧血の重症度と予後の再検討.臨床血液(1978)19,1634-1640.
16) Shinohara K, Matsumoto N, Tajiri M, Nakashima K, Ariyosyi K, Miwa A and Miyaji T : Oxymetholone treatment in aplastic anemia. Acta Haematol Jpn (1974) 37, 255-265.
17) 高橋 功:前白血病状態に関する臨床的研究,第二編 再生不良性貧血様前白血病状態と特発性再生不良性貧血との関連.岡山医誌(1975)87,33-50.
18) Chen MG : Age-related changes in hematopoietic stem cell populations of a long-lived hybrid mouse. J Cell Physiol (1971) 78, 225-232.
19) Vacek A, Bartonickova A and Tkadlecek L : Age dopendence of the number of the stem cells in haemopoietic tissues of rats. Cell Tissue Kinet (1976) 9, 1-8.
20) 鈴木千里:高齢者における血液肝細胞の研究.東京医科大学誌(1981)39,871-881.
21) Lipschitz DA, Udupa KB, Militon KY and Thompson CO : Effect of age on hematopoiesis in man. Blood (1984) 63, 502-509.
22) 森真由美:造血幹細胞からみた老年者の貧血とその対策.日老医誌(1982)19,245-248.
23) 鈴木千里:造血幹細胞からみた老年者の貧血とその対策.日老医誌(1982)19,249-250.
24) 白倉卓夫,田中英雄,武田敏雄,村井善郎:老年者のhemoglobin濃度と血中erythropoietin活性値.医学のあゆみ(1975)93,316-317.
25) Mori M, Marui Y, Hirai M, Kawakami M, Saito T, Takanashi N, Urabe A and Takaku F : Serum erythropoietin titers in the aged. Mech Age Devel (1988) 46, 105-109.
26) Earney WW, Earney AJ and Graham JD : Effect of aging on granulopoietic activity. J Am Geriat Soc (1975) 23, 175-179.
27) 長田 建,竹内 誠,青山重男,高橋 功,木村郁郎:高齢者における末梢単核球CFS活性の検討.第30回日本老年医学会(1988).
28) 広田 豊,藤岡成徳,与那原良夫,児玉順三,中山志郎,瀬崎達雄:国立病院再不貧共同研究班集計成績,治療(retrospective study)の臨床統計的検討;昭和49年度事業集 再生不良性貧血Ⅲ,再生不良性貧血の成因と治療,予防に関する研究班(1975)pp471-477.
29) 広田 豊:治療検討計画(Prospective study)による蛋白同化ホルモン,男性ホルモンの再生不良性貧血に対する治療成績(第2報);昭和50年度業績集 再生不良性貧血Ⅳ,再生不良性貧血の成因と治療,予防に関する研究班(1976)pp475-490.
30)Mackay IR, Whittingham SF and Mathews JD : The immunoepidemiology of aging. Immunology and Aging (1977) 35-49.
31) Makinodan T, James SJ, Inamizu T and Chang MP : Immunologic basis for susceptibility to infection in the aged. gerontology (1984) 30, 279-289.
32) Effors RB and Walford RL : Dimminished T-cell response to infuenza virus in aged mice. Immunology (1983) 49, 387-392.
33) Ford PM : The immunology of aging. Clin Rheum Dis (1986) 12, 1-10.
34) Inamizu T, Chang MP and Makinodam T : Decline in interleukin(IL)-1 production with age. Gerontolgist (1983) 23, 249.
35) 菊地昌弘,岡村秀樹,竹下盛年,田淵正延:再生不良性貧血剖検例における死因の年代的変貌;昭和57年度研究報告書,厚生省特定疾患特発性造血障害調査研究班(1983)pp49-51.
36) 高久史麿:老年者再生不良性貧血.Geriat Med(1984)22,487-491.
37) 桜田恵右,宮崎 保,洞田克己,高橋香織:再生不良性貧血.老人科診療(1984)5,28-33.
38) 柴田 昭,鳥羽 健:再生不良性貧血.臨床と研究(1990)67,25-31.
39) 川上睦美,堤  久,平井真希子,熊川泰郎,倉口寛一,黒沢晋一郎,村井善郎,森真由美:老年者のMDS.臨床血液(1990)31,296-300.
40) 広田 豊,浜島信之,青木国雄:Prospective studyに基づく再不貧に対するアンドロジェン療法患者の長期follow up―依存性,長時間後の副作用,生存曲線の解析を中心として―;昭和56年度研究報告書,厚生省特定疾患特発性造血障害調査研究班(1982)pp351-363.
41) 山岸司久,小熊 茂,吉田弥太郎,内野治人:再生不良性貧血の予後因子.臨床血液(1990)31,168-171.
Copyright Holders
File Version
Eprints Journal Name