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ID 13782
Eprint ID
13782
FullText URL
Thumnail 106_23.pdf 1.72 MB
Title Alternative
T-cell subsets in lung tissue and BALF from patients with interstitial pneumonia
Author
Namba, Jiro
Abstract
The cellular components in bronchoalveolar lavage fluids (BALF) and biopsied lung tissues of patients with various types of interstitial pneumonia were analyzed to clarify cellular kinetics in the lung. The T-cell subsets of lymphocytes in BALF and biopsied lung tissues were examined in 7 cases of hypersensitivity pneumonitis (HP), 2 cases of sarcoidosis (Sar), one case of idiopathic interstitial pneumonia (IIP) and 2 cases of rheumatoid arthritis with interstitial pneumonia (RA+IP). The T-cell subsets in BALF were analyzed by flow cytometry and the T-cell subsets in lung tissue were detected in frsh frozen and thin-sliced specimens using an avidine-biotine complex (ABC) kit. The mean CD4/CD8 ratio in BALF was 0.36 in HP, 3.1 in Sar, 1.07 in IIP and 2.59 in RA+IP, while the mean CD4/CD8 ratio in lung tissues was 0.52 in HP, 2.59 in Sar, 1.11 in IIP and 2.25 in RA+IP, respectively. The ratios of CD4/CD8 in BALF and lung tissues from patients with these various interstitial pneumonia showed a positive correlation. Significant correlation was seen between CD4/CD8 rations of the alveolar portion findings indicate that BAF findings reflect the changes in the lung tissues, although BALF might reflect only a part of the changes in the whole lung.
Keywords
bronchoalveolar lavage (BAL)
transbronchial lung biopsy (TBLB)
immunoperoxidase staining
T-cell subset
Note
原著
Published Date
1994-02
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
23
End Page
32
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
http://www.https://www.jstage.jst.go.jp/article/joma1947/106/1-2/106_1-2_23/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma