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ID 13728
Eprint ID
13728
FullText URL
Thumnail 107_111.pdf 413 KB
Title Alternative
Free radical generation induced by prosthesis materials in the skin and muscle of rats
Author
Endo, Yumi
Abstract
The effect of pellets of prosthesis materials on free radicals were examined using electron spin resonance spectrometry. Pellets used were titanium, alumina, ziruconia, an alloy of cobalt with chromium and polyethlene. These pellets were implanted in the abdominal skin and thigh muscle tissue of rats. Animals were sacrificed by decapitation at 1, 3, 20 hours and 2 and 4 weeks after implantation and subcutaneous and muscle tissues were dissected. Hydroxyl radicals and carbon centerd radicals were analyzed as spin adducts of spin trap, 5, 5-dimethyl-1-pyrroline-N-oxide. Hydroxyl and carbon centered radicals in the skin and muscle tissues were increased 1-3 hours after the implantation of these materials and these changes were almost recovered to the normal level 20 hours after the implantation except for alumina and ziruconia in the muscle. However, hydroxyl radicals and/or carbon centered radicals were increased in the skin 4 weeks after the implantation of zirconia, titanium, an alloy of cobalt with chromium and polyetylene. These results suggest that the subacute stage after the implantation of particles of prostheseis materials into the skin and muscle tissues induces the generation of free radicals and than these free radicals may produce tissue damage.
Keywords
フリーラジカル
筋組織
皮膚組織
医用インプラント材原料
ラット
Note
原著
Published Date
1995-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume107
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
111
End Page
119
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/107/7-8/107_7-8_111/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma